IV ibu for preterm newborns

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IV ibuprofen for preterm newborns
A systematic review of trials of intravenous ibuprofen and indomethacin for patent ductus arteriosus (PDA) in premature infants has concluded that both have a role (Semin Perinatol 2006;30:114-20).

The two drugs were similarly effective in a direct comparative trial but indomethacin was associated with abnormal renal function and decreased mesenteric and cerebral blood flow. However, ibuprofen did not reduce the risk of intraventricular haemorrhage. This led the authors to suggest that indomethacin may be preferred on the first day of life, when there is a risk of intraventricular haemorrhage; thereafter, ibuprofen is probably the drug of choice for PDA closure due to its better adverse event profile.

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