No sig risk of cardiac events with ibu

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'No significant risk of serious cardiac events' with ibuprofen
A new study has concluded that ibuprofen is not associated with an increased risk of serious cardiac events (eular2006SCIE-abstract).

The findings come from a nested case control study of the Kaiser Health Plan in California, previously used to determine the risks of COX-2 selective NSAIDs (see Lancet 2005;365:475-81). Comparison of NSAID use by 8,143 patients with acute myocardial infarction or sudden cardiac death with that in over 32,000 matched controls showed that ibuprofen was not associated with a statistically significant increased risk (odds ratio, OR, 1.078; CI95% 0.973- 1.195). There were similar findings for diclofenac, piroxicam, etodolac, sulindac and nabumetone. However, both naproxen (OR 1.143, CI95% 1.002 - 1.303) and indomethacin (OR 1.270, CI95% 1.037 - 1.556) were associated with slightly increased risks. The risk with indomethacin approaches that associated with rofecoxib, the authors note.

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