Alternating antipyretics in febrile children

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Dose-response for ibuprofen analgesia
It's official: higher doses of OTC analgesics are significantly more effective than lower doses, according to a systematic review of randomised controlled trials by Oxford pain specialists (Br J Clin Pharmacol 2006;July 21: Epub ahead of print).

Their analysis of data pooled from fifty trials showed that 400 mg of ibuprofen provides superior analgesia to 200 mg. The number of people who would need to be treated with the higher dose for one person to obtain additional benefit (the number needed to treat, or NNT) was 10. Similar differences were found for aspirin (1000/1200 mg superior to 500/600 mg; NNT 16) and paracetamol (1000 mg superior to 500 mg; NNT 9).

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